Nosh-shpa (drotaverine): overdose and lethal dose

1Why might a child vomit bile?

Vomiting is easy to recognize; the main symptoms of this condition may be:

• stomach urges;
• contractions of the esophagus;
• nausea;
• all content will be released last.

Vomiting bile in a child indicates that the following organs are affected:

• pancreas;
• liver;
• bile ducts.

Bile has a yellow-green color, and there is a constant bitter taste in the mouth that cannot be interrupted and eliminated. Therefore, if babies begin to vomit bile, you need to find out the cause of this condition in order to adequately respond to it. It is better not to self-medicate, but to call a doctor, especially if vomiting does not go away for a long time. Only a specialist can determine what to do if vomiting occurs.

I feel nauseous, can anything help me get rid of this feeling? There is nothing more.

1. Try to always have something in your stomach, do not let yourself get too hungry. An empty stomach can lead to increased nausea. 2. Saltine crackers can help settle your stomach, so always have some on hand. They are very helpful in the morning or even in the middle of the night if you wake up feeling nauseous. 3. Avoid the following foods: high fat foods, fried foods, spicy foods, sour foods and heavy foods. All of the above are slower to digest and can cause irritation to the digestive system. 4. Foods high in vitamin B have the ability to reduce nausea, so we recommend eating more of these foods: Unprocessed grains such as wheat or oats, fish and seafood, poultry and animal meats, eggs, dairy products such as milk and yogurt , leafy green vegetables, beans and peas. 5. To settle your stomach and calm nausea, try ginger. Ginger juice is especially good if it is made from real ginger. You can try ginger tea or ginger cookies, and even use ginger in your cooking. 6. To combat morning sickness, you can experiment with some natural remedies: papaya enzyme, vitamin B-6, acupressure, or even yoga or massage. 7. Be sure to consume more water between meals. A good choice is NARZAN mineral water with a slice of lemon. 8. To relieve nausea, you should take prenatal vitamins with food. Don't forget that an empty stomach itself can lead to nausea. 9. Avoid taking iron supplements during the first trimester unless you are anemic. Iron can be very difficult for your stomach to absorb. 10. When you feel normal, try to eat healthy, exercise, and wait for your little one to arrive. And as you approach your second trimester of pregnancy, remember that the real cure for morning sickness is time.

No-Spa relieves spasms, i.e. acts as a pain reliever.

I’m sitting sad but this is only temporary. I ate a Snickers chocolate bar and now I’m pregnant.

take a pregnancy test

No-spa relieves spasms, so it can relieve some of the nausea. You need something sour, a piece of lemon, a sour apple relieves nausea. Health and good luck to you))))

maybe there is still kefir in the refrigerator? drink as much as you can, for example a glass, if it’s not toxic, of course

noshpa is an antispasmodic, it obviously won’t help you; cerukal will help with nausea

try charcoal tablets, a couple of pieces of warm tea without sugar, but for pain and not for nausea, millet or pearl barley porridge is not very thick, do not eat meat and sweets for at least a day and you will feel better, of course, if it is not pregnancy

No from feeling. Not very effective against nausea. You decide whether you have a sensitive or medical condition.

Tomato juice, reni or hastal (relieves nausea and heartburn)

Cerucal helps with nausea

go to the pharmacy sometime and buy Filterumsti!

touch.otvet.mail.ru

2Causes of vomiting

First of all, parents must calm down in order to correctly determine the cause of the appearance of bile. The main reasons include the following.

Eating so-called “adult” food, which usually includes foods inappropriate for age, fatty and spicy foods. For example, chips, snacks, crackers, etc. Parents, wanting to switch their children to a more adult diet, do not take into account the characteristics of each age and the body’s ability to digest enzymes. For some foods, the enzyme system in the body may not be sufficiently developed, so as early as eight to nine years old, a child may experience vomiting accompanied by bile.

Gallbladder disease. This may be cholecystitis or cholelithiasis, which are caused by improper functioning of the stomach. The release of a large amount of bile into the stomach can provoke a gag reflex, nausea and an attack of vomiting.

The presence of viral hepatitis in the acute stage. This is why the baby vomits bile, stools are disrupted, and damage to the liver and bile ducts occurs. This is due to a virus that penetrates the body and begins to actively act in the body of children.

Children often experience stomach upset due to intestinal infections caused by bacteria and viruses. Due to intoxication, the body puts up a protective barrier and begins to react to the presence of irritants by vomiting. With repeated emptying of the stomach, bile begins to flow into it, which begins to come out with repeated vomiting.

Foods that the child’s body cannot digest enter the stomach. Therefore, food begins to gradually accumulate and linger in the body. As a result, leftover food can ferment and rot, and the body must get rid of these toxins. The consequence of such processes is vomiting with the release of bile.

Sometimes vomiting is a symptom of more serious diseases, when the body is poisoned, a viral and bacterial attack is observed. Only doctors can provide qualified assistance in such cases, and they must rinse the stomach in various ways.

Group of enzyme preparations

When poisoned by food or alcohol, all digestive mechanisms are affected, so it is necessary to use enzyme agents to improve digestion. The drugs normalize digestive functions, restore the processes of processing proteins, fats, and carbohydrates. The following enzyme medications are being considered:

As a result of taking it, the load on the pancreas is reduced. The medications should be taken according to the instructions, for example, Mezim should be taken twice a day. Drink Mezim one tablet at a time.

3What needs to be done?

Children whose bodies are affected by infections, bacteria, toxins or other substances that cause vomiting and bile secretion should receive first aid. First, parents must call a doctor who will provide assistance, and before that the following medical measures must be taken.

You need to calm the child down, encourage him so that he stops crying. Rinse the stomach, but not with potassium permanganate. Its use is strictly prohibited. You need to heat the water, cool it and give the child two or three glasses to drink. This will trigger the gag reflex and help empty your stomach. The child should drink quickly, while in a sitting position, without taking long breaks between sips. But it is worth remembering that vomiting can only be caused when children have not been diagnosed with various diseases and pathologies.

Give the child smecta and activated carbon, taking into account his age and weight. Smecta needs to be dissolved in warm water and make sure that kids drink it in small sips. Activated carbon is given at the rate of one tablet per ten kilograms of weight. Place the baby on his side with a high pillow under his head. Measure the temperature, and if it is higher than normal, then give Ibufen or children's Parcetamol to drink.

In order to avoid dehydration, you need to give mineral water to drink, but always still water. It’s better to brew rosehip, which is very effective against vomiting and bile. You need to drink liquid every fifteen minutes, drink in small sips, very slowly.

Eating is prohibited for several hours after washing. It is better for the baby to fall asleep and sleep for several hours. When he wakes up, you need to give him a small portion of chicken or beef broth. The diet is expanded gradually and only with the permission of a doctor. It is strictly forbidden to eat spicy and salty foods; you should limit your consumption of sweets.

A doctor should be called if vomiting continues for a long time and does not stop. There is no need to stop a single attack of vomiting; the body copes with such situations on its own. The doctor should order tests to determine the cause of vomiting and bile secretion. If these signs are caused by a specific disease, then a course of drug treatment will be prescribed.

Medicines are selected in order to eliminate vomiting, prevent the development of the disease, so that the vomiting goes away completely. Various choleretic herbal teas will help relieve attacks.

First steps when vomiting and after it

First of all, it should be noted that in most cases it is impossible to resist the gag reflex, since it is a protective measure of the body against intoxication and poisoning. When a person begins to vomit, poisonous substances (toxins) come out along with the contents of the stomach, which promotes recovery.

However, there is one exception that you should definitely pay attention to - this is if the vomit is stained with blood, or the vomit is dark (almost black) in color.

pharmachologic effect

Due to the effect of drotaverine on the body, smooth muscle contractions are reduced. The level of calcium in muscle tissue decreases, which produces a relaxing effect. The drug does not affect the nervous system, only smooth muscle cells. Does not interfere with the functioning of the heart and blood vessels.

After entering the digestive system, it is absorbed, entering the bloodstream, spreading through the tissues of the body and reaching smooth muscle cells. The lack of effect of the drug on the central nervous system occurs due to the inability to overcome the blood-brain barrier separating it from the bloodstream. The period of elimination of the drug from the body is 16 hours.

Analogues of noshpa

Analogs of No-shpa are drugs with similar therapeutic effects as the original. The drug has few similar drugs. The most popular of them are:

• drotaverine;
• drotaverine Forte;
• papaverine;
• spasmol;
• spasmonet.

It is recommended to remember that analogues may have different contraindications and side effects. Therefore, before use, you must carefully study the instructions.

Irritation, a feeling of sand in the eyes, redness are only minor inconveniences with impaired vision. Scientists have proven that decreased vision in 92% of cases ends in blindness.

Crystal Eyes is the best remedy for restoring vision at any age.

Purpose

The medication is used for:

• stomach ulcer, duodenal ulcer;
• proctitis – inflammation of the intestinal mucosa;
• coronary spasms;
• development of spastic constipation or colitis - chronic inflammation of the intestinal mucosa, accompanied by constipation;
• gastroduodenitis - inflammation of the gastric mucosa or duodenum;
• the appearance of endarteritis - inflammation of the lining of arterial vessels.

Additionally used to eliminate or prevent muscle spasms of the abdominal organs:

• renal or intestinal;
• bile ducts;
• with biliary colic;
• with cholecystitis - inflammation of the gallbladder;
• with the development of dyskinesia of the gallbladder - a violation of the outflow of bile.

Used to eliminate the threat of miscarriage and prevent premature birth. Also, to relieve tension in the uterine pharynx during childbirth, if there is prolonged dilatation, or to relieve postpartum contractions. It is recommended for use if cholecystography is performed - x-ray with contrast.

Indications

Prescribed if the following indications exist:

• the appearance of muscle spasms in the urinary system, occurring due to cystitis, pyelitis, stones in the ureter;
• muscle strain due to pathologies of the digestive system: ulcers, gastritis, enteritis;
• spasms of the muscular system caused by diseases of the biliary tract such as pericholecystitis, cholecystolithiasis, cholecystitis;
• the appearance of headaches due to muscle strain;
• dysmenorrhea – severe pain during menstruation.

In addition, the solution is used:

• with spasms of blood vessels located in the brain or peripheral arteries;
• with postoperative colic, due to gas retention in the digestive system;
• to prepare for instrumental research;
• algodismenorrhea – regular pain during menstruation, accompanied by hormonal, metabolic, and neurological disorders.

Release form

There are the following types:

• Green round tablets. They contain 40 mg of active ingredient and are sold in packages of 6, 20 and 24 pieces per package.
• Solution for injection with a greenish tint. Ampoules containing 20 or 40 mg of drotaverine. Each ampoule contains 2 ml. Each package contains 5 or 25 containers.

Contraindications

No-spa is prohibited in a number of pathological or physiological conditions of a person, which include:

• the presence of individual intolerance to the active substance or auxiliary elements;
• renal failure;
• decrease in the functionality of the liver due to pathologies, diseases of the organ;
• heart failure, in acute or chronic form and at the stage of decompensation;
• the presence of lactose intolerance, which makes it impossible to use No-shpu, contains lactose as an auxiliary component;
• age less than 6 years;
• breastfeeding a child.

Before starting to use the drug, it is recommended to check for any contraindications to its use in order to prevent complications and allergies.

Consequences of poisoning

No-shpa poisoning can have serious consequences. The drug can provoke the development of renal and liver failure. Patients with vascular atherosclerosis may develop cardiovascular complications. The most tragic consequence is death due to respiratory arrest and the development of asystole.

As you can see, even such a seemingly harmless drug can cause severe poisoning. Therefore, it is necessary to take No-shpu and other analogues of Drotaverine only as prescribed by a doctor, and avoid uncontrolled use of the medicine. Symptoms of poisoning are nonspecific. Cardiac disorders and general malaise come to the fore, with which patients consult a doctor, not suspecting that these are signs of poisoning. Difficulties in timely diagnosis make poisoning more dangerous and the consequences more severe.

No-spa is a well-known medicine used for spasmodic manifestations. However, not many people know that the drug can be used for intoxication. How does No-shpa work in case of poisoning? How many tablets are allowed to take?

Instructions and dosage

To stabilize the condition of an adult, the daily dosage is 120-240 mg of the drug, 3-6 tablets, divided into 2-3 doses during the day. In this case, the maximum possible single dose should not exceed 2 tablets.

For a child under 12 years of age, the daily dosage of the drug is 2 tablets in 2 doses. For adolescents over 12 years of age, the daily dose is 4 tablets in 2-4 doses.

It is not recommended to use the product independently for more than 2 days without a doctor’s prescription. If there is no improvement during this time, it is recommended to go to the hospital to make an accurate diagnosis and choose the correct treatment regimen. To use the drug as an addition to main therapy, it should not be used without a doctor’s prescription for longer than 3 days.

The drug in the form of an injection solution for adults is prescribed up to 240 mg per day, administered intramuscularly 3 times. Necessary for persons with stones in the urinary or biliary tract, as well as for acute colic. Up to 80 mg of medication is administered slowly and one-time.

The absorption period of the drug in tablet form after administration is 12 minutes.

Folk remedies for nausea

• Warm linden tea: relieves inflammation, has a healing effect on the gastric mucosa, and activates digestion.
• Melissa: 5 tbsp. spoons of dry herb are poured with 1 liter of boiling water (preferably in a thermos) and allowed to brew for 3 hours. Drink half a glass 4-5 times a day before meals.
• Ginger: Chew a piece of raw ginger (do not swallow) or make a drink. Pour 1 teaspoon of grated ginger into 1 glass of boiling water, cover and leave for 10-15 minutes. Then add 1 teaspoon of fresh lemon juice and the same amount of honey. The drink is drunk warm, but not more than 3 glasses per day.
• A mixture of lemon juice and honey for instant relief from nausea: 1 tsp. fresh lemon juice and the same amount of honey are mixed and taken immediately.
• Crushed cloves (spice): take 0.5 g before meals.
• Cucumber pickle: take 4 sips, no more (the digestive process starts).

Side effects

When used correctly, the medication rarely causes side effects. However, it is important to consider that during treatment the following may occur:

• low blood pressure;
• arrhythmias;
• insomnia;
• headache;
• loss of orientation;
• functional intestinal disorders: constipation, diarrhea;
• nausea turning into vomiting;
• hypersensitivity reactions.

With intravenous or intramuscular administration, a reaction may occur at the injection site.

Overdose

As a result of excessive intake of No-shpa, cardiac arrhythmia can occur, the possibility of cardiac conduction is reduced, leading to cardiac arrest and death. The lethal dose of the drug is 40-60 tablets of 40 mg each, leading to death 2 hours after consumption.

If the dose is excessive, it is required to be observed by doctors in a hospital setting. Symptomatic therapy is prescribed, consisting of gastric and intestinal lavage, maintaining body functions important for life.

If the nausea doesn't go away...

It is important to know what nausea signals and why a person feels sick at times. And if this is not a sign of pregnancy, overeating or motion sickness, you should consult a doctor to find out the cause.

The drug No-shpa is an antispasmodic with myotropic action. It reduces the tone of smooth muscles, reduces the excitability of internal organs, and dilates blood vessels. In terms of effectiveness, this antispasmodic is superior to all similar drugs. The medicine helps reduce pain after use within 2-4 minutes.

Interaction with other medications

When used simultaneously with No-shpa with other antispasmodics, it enhances their effect: Atropine, Papaverine, Bendazole. If used together with antidepressants, blood pressure decreases, and when used with morphine, reduces its activity. When the drug is used with Phenobarbital, the ability to eliminate spasms is enhanced, and when used simultaneously with Levodova, a drug for the treatment of Parkinson's disease, tremor increases.

Most of the components of the drug interact with plasma proteins, which are contained in the blood and perform a nutritional function. Leads to intoxication from taking.

No-shpa tablets

Pharmacological properties make the drug effective against antispasmodic pain of various origins. No-spa affects the smooth muscles of the cardiovascular, genitourinary, biliary, and gastrointestinal systems. The country of origin of the drug is Hungary. No-shpa is available in tablets or ampoules with a solution for intramuscular injection. The main active ingredient of the drug is drotaverine hydrochloride. The auxiliary components of the drug include:

• lactose monohydrate;
• corn starch;
• polyvidone;
• talc;
• Magnesium stearate.

Properties

Drotaverine is an isoquinoline derivative that has an antispasmodic effect on smooth muscles by inhibiting the PDE 4 enzyme. This component of synthetic origin, due to the inactivation of the myosin kinase chain, relaxes the muscles. What does Drotaverine help with? The substance is useful in the treatment of diseases during which gastrointestinal spasms occur, and for diseases accompanied by motor hyperfunction.

The properties of No-Spa to increase blood circulation in tissues leads to the ability to dilate blood vessels, which alleviates headaches and reduces high fever. The drug is completely absorbed after oral and parenteral administration. It is 95% bound to blood plasma and after the first metabolism, 65% of the dose enters the bloodstream unchanged. Drotaverine is metabolized in the liver, partially excreted after 10 hours, and completely after 72 hours with urine and feces.

How it works

The chemical structure and pharmacological properties of No-shpa are similar to Papaverine, but it has a longer and more pronounced effect. The effect of the drug is expressed by inhibition of the entry of calcium ions into smooth muscle cells. This leads to dilation of the coronary vessels, a decrease in the tone of intestinal motility and muscle fibers. Treatment with No-shpa does not affect the central nervous system and the autonomic nervous system.

What does it look like?

The secretion of bile with vomit gives it a yellowish or greenish color. The contents of the stomach are thrown out through the mouth due to a sharp contraction of the muscles of the diaphragm, the stomach itself and the abdominal wall.

Before vomiting occurs, the child usually feels an attack of nausea, turns pale, and may experience chills. The more episodes of vomiting a child has, the more weakened he becomes and the higher the risk of developing dehydration.

Possible reasons

Most often, vomiting bile is a symptom of food poisoning or another disease of the digestive tract that causes repeated bouts of vomiting. Often, such vomiting is accompanied by other symptoms of gastrointestinal damage - diarrhea, severe abdominal pain, chills, fever.

The causes of vomiting, in which bile impurities are determined, are called:

• Intestinal infection.
• Gallbladder diseases.
• Pylorospasm.
• Acute appendicitis.
• Biliary colic.
• Intestinal obstruction.
• Food poisoning.
• Congenital narrowing of the upper digestive tract.
• Renal colic.
• Vascular thrombosis in the intestine.
• Brain lesions.

Among the non-dangerous factors that cause the reflux of bile into the child’s stomach and its removal with vomit include mental overload, active games, and consumption of very fatty and spicy foods. In such cases, vomiting often occurs once or twice, and the general condition of the child is almost not disturbed.

Use of antispasmodics

A common symptom of poisoning is painful spasms in the intestines and stomach. Therefore, in case of poisoning, painkillers are used. What kind of means are these? The group of antispasmodics includes:

No-shpa is the most famous representative of this group. The effect of no-shpa begins 12 minutes after administration, as a result, smooth muscle spasm is relieved. How many times a day should I take no-shpa? In case of poisoning, you can take two tablets three times a day. Despite the effectiveness of no-shpa, it should be understood that it is only indicated for relieving spasms. No-spa does not treat the cause of poisoning.

Read also: How long should you drink alcohol after general anesthesia?

Should I call a doctor?

Since the appearance of vomiting with bile impurities can be a sign of quite serious illnesses, calling a doctor is recommended in all cases of such a symptom occurring in childhood.

It is especially urgent to call a doctor in the following situations:

• The child complains of severe abdominal pain.
• The baby has a high temperature.
• The child vomited repeatedly and was accompanied by diarrhea.
• The child ate spoiled food or took any medications before vomiting.
• You notice signs of dehydration in your child.

Description of the disease

First, you need to understand what nausea is. The unpleasant sensation is accompanied by a painful feeling in the stomach; it can appear in both adults and children. When nausea occurs, a person’s activity decreases, and a feeling of discomfort and malaise appears. The result of resolving the problem can be several outcomes: the feeling of nausea will pass without complications or vomiting will appear. Vomiting is the coordinated work of the abdominal muscles and diaphragm, which provoke a jerking action to cleanse the body of toxins that have entered it. After the stomach is completely empty, the patient's condition improves slightly.

It is important to know that most often the appearance of nausea and vomiting is caused by diseases of the gastrointestinal tract. To find out the cause, it is necessary to consult a doctor, since in addition to the gastrointestinal tract problem, there is also a large list of possible causes for its occurrence.

First aid

1. First of all, parents should calm themselves and their child, as episodes of vomiting are always alarming. You need to call a doctor and wait for him, without leaving your baby for a minute.
2. To prevent the contents of the digestive tract from entering the baby's respiratory system, make sure that the baby is not lying on his back. The optimal position after vomiting is vertical. If the child is lying down, turn his head to the side.
3. It is important to start giving your child fluids right away to prevent dehydration from developing. The best drinking option is considered to be solutions of glucose and salts, which are made from pharmaceutical powder preparations. You can also prepare similar solutions at home using sugar, soda and salt. Such solutions are given in small portions (a teaspoon) every five to ten minutes.
4. No medications, especially antibiotics and antiemetics, should be given until the baby is examined by a doctor.

Sources

• https://gastri.ru/rebenka-rvet-zhelchyu.html
• https://prootravlenie.ru/pomoshh/chto-delat-pri-rvote-kakie-lekarstva-pit
• https://orvote.ru/lekarstva/no-shpa.html
• https://www.o-krohe.ru/bolezni-rebenka/rvota/zhelch/