Overdose of Aevit: symptoms, consequences, help

Aevit is an inexpensive, time-tested drug that consists of two vitamins - A and E. Both vitamins are involved in the regeneration of skin cells, and both are soluble only in oil. Therefore, Aevit capsules are produced on an oil base. An overdose of Aevit can cause an allergic reaction and other complications, which will be discussed in this article.

How does the drug work?

One capsule contains a fairly high dose of vitamins. It exceeds the recommended daily amounts of such substances. Therefore, Aevit is not intended for prophylactic use, but for treatment. The combination of two vitamins is harmonious for a complex effect on a number of pathologies.

The action of vitamin A (retinol) is as follows:

Restoration and activation of redox reactions.
Regulation of protein formation processes.
Normalization of metabolic processes.
Restoring healthy bones, teeth, regulating the amount of fat deposits.
Formation of new body cells.
Slowing down the aging process of the body.
Restoring normal vision, combating so-called night blindness.
Fighting infectious pathologies, increasing immunity. Thanks to this, the body fights bacteria and viruses much better, and if a person gets sick, he tolerates the disease much better and recovers faster.
Improved skin condition: wounds and small cuts heal much faster.
Normalization of hormonal balance.
Fighting cancer pathologies.

Vitamin E has the following effect on the human body:

Strengthening the immune system.
Normalization of myocardial activity..
“Thinning” of blood and fighting atherosclerotic plaques.
Combating the formation of free radicals.
Normalization of the sex glands of men and women. The vitamin also takes part in the formation of sex hormones.
Enrichment of cells and tissues with oxygen, preventing hypooxygenation.

According to many experts, tocopherol is rightly called the “vitamin of life.” It is considered essential because it is not formed in the body, but enters it from the outside.

Aevit cream - instructions for use

Aevit - as a cosmetic product.
You can see Aevit creams in pharmacies and stores. These are not medicines, but cosmetics produced under the LIBREDERM brand.

There are different creams:

Nourishing night. While you sleep, this product rejuvenates the skin, restores its smoothness and elasticity, moisturizes and nourishes it, and accelerates regeneration.
For face. The cream is intended for use at any time of the day. The product refreshes the skin and has a pronounced anti-aging effect.
With blueberries against puffiness for the skin around the eyes. The product gets rid of bags and dark circles under the eyes, makes fine wrinkles less visible.
For hands. Rejuvenates the skin, slows down the aging process, fights age-related pigmentation.

Directions for use: cleanse the skin and massage a small amount of the selected cream over it. Products intended for the care of the skin around the eyes should be applied with patting movements of the fingertips in the morning and evening (about 2 hours before bedtime).

Danger of overdose

An overdose of Aevita is especially dangerous for children. The child's body does not always adequately respond to the entry of foreign foreign substances into it. As a result, children can often develop signs of an allergic reaction.

Even if a child eats one capsule of Aevit, he may develop an allergy. The danger is represented by atopic dermatitis, and in especially rare cases, with increased sensitivity to the drug, angioedema and anaphylactic shock may develop. Quincke's edema is very dangerous because it can cause suffocation in a small organism.

Adults can also develop a dangerous condition. Since the body is capable of accumulating the active components that make up the drug Aevit, an overdose with excessive long-term use of such a multivitamin is almost inevitable. Allergic manifestations in adults occur less frequently and are less pronounced. But nevertheless, long-term use of the drug (especially as self-medication) causes the following phenomena in adults:

Increased blood pressure.
Thrombcytopenia and leukopenia.
Weakness and increased fatigue.
Suppression of the liver and kidneys.
Enterocolitis.
Accumulation of fluid in the abdominal cavity (ascites).
Vascular ruptures (often they cause the appearance of numerous hematomas on the body and the “red eye” effect).

No deaths were observed with the use of tocopherol. Sources indicate that even a 20-fold excess of the recommended daily dose does not lead to death, despite the fact that overdose phenomena are observed in the body. Severe clinical symptoms of intoxication are observed when the concentration of vitamin E in the blood is more than 40 mg per 100 ml of blood.

Contraindications

The vitamin preparation should not be taken in case of thyrotoxicosis with intoxication. A high dose of vitamin E leads to disruption of the production of thyroid hormones. It is contraindicated to take Aevit if the patient suffers from chronic glomerulonephritis, otherwise kidney failure may occur (see Kidney poisoning).

Congestive heart failure is also a contraindication to drug treatment. An excessive dose of vitamin E, which the drug contains, can provoke the formation of blood clots, which will lead to obstruction of blood vessels and inflammation of their walls.

It is not advisable for people with a history of cholecystitis to take Aevit, since large amounts of vitamin A contribute to the thickening of bile and the formation of stones in the bile ducts. You cannot drink Aevit if you have hypervitaminosis A or E, otherwise severe poisoning with the drug will occur.

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Aevit is contraindicated for the treatment of children under 14 years of age, since its high content of vitamins is harmful to the child’s body.

Aevit should be taken with caution if you have diseases such as:

cardiac ischemia with regular attacks of angina pectoris;
heart attack (myocardium);
blood clotting disorder;
pyelonephritis.

If you have the listed pathologies, you should definitely consult a doctor before treatment with the drug.

Important! During pregnancy, you should drink Aevit very carefully; only in extreme cases can a doctor prescribe a course of therapy with a vitamin complex. It is not recommended to use the medicine in the first trimester, as the drug can cause abnormalities in the development of the unborn child. During breastfeeding, treatment with Aevit is possible only with the permission of a doctor. In this case, it is recommended to stop breastfeeding.

Conclusion

Despite the fact that Aevit is a vitamin preparation, it is still considered a medicine. It can only be taken as directed and strictly in the indicated doses. Before using the vitamin complex, you need to take into account existing diseases, including those of a chronic nature, for which the drug cannot be used. Compliance with all the rules for using Aevita eliminates the appearance of symptoms of vitamin overdose and the occurrence of serious health consequences.

Aevit for children

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How does it manifest?

Symptoms of acute overdose (if you take a large number of capsules at once) are as follows:

drowsiness, severe weakness and lethargy;
diplopia;
severe dizziness;
severe vomiting;
dry mucous membranes, peeling of the skin;
nervous excitement;
diarrhea;
sharp pain in the stomach;
increase in liver size;
the appearance of bleeding.

Long-term use of this medicine in non-recommended high doses causes the following changes and pathological conditions in the body:

Tremor of small muscles.
Severe alopecia.
The appearance of spots on the skin, in particular on the soles and palms.
Changes in blood composition (anemia).
Disorders of the normal functioning of the urinary system.
Children may experience early closure of growth plates.
Visual perception disorders.
Malformations of the spine and other parts of the musculoskeletal system.
Severe sexual dysfunction.
Thrombophlebitis, in severe cases - thromboembolism.
Increased bilirubin levels in the blood.
Retinal hemorrhage.
Colitis, hepatitis.

Aevit and other drugs

The following medications enhance the toxic effects of the multivitamin. Manifestations of overdose can occur in a person even from recommended quantities.

Estrogens significantly increase the effect of vitamin A and the severity of symptoms of retinol overdose.
Preparations containing calcium increase the content of this mineral in the body.
Antibiotics together with Aevit increase intracranial pressure.
Warfarin and other anticoagulants increase the risk of hemorrhage.
Neomycin and Colestipol reduce the absorption of the drug, so to achieve the desired effect the dose must be increased. This, in turn, is fraught with the appearance of signs of overdose.

Daily dose of vitamin A

Vitamin A contains retinol, retinal and retinoic acid. All of them are unstable, therefore, in order to achieve stability, they are combined with ethers. Retinol acetate or palmitate is a “sealed” form of vitamin A. Its most active part is retinol.

High retinol content is found in liver, eggs, and dairy products. And plant foods contain a precursor to vitamin A - carotene. Carrots, peppers, and tomatoes are rich in it.

What is the daily norm for a person?

The daily dose for men is 900 mcg or 0.9 mg.
The daily dose for women is 700 mcg (0.7 mg).

The permissible maximum daily dose for adults is 3000 mcg (3 mg).

Daily value for children:

from 0 to 12 months - 0.4 mg;
from one to three years - 0.45 mg;
from four to six years - 0.5 mg;
from seven to ten years - 0.7 mg.

It becomes clear at what doses the toxic effect of vitamin A on the body is observed - an excess is guaranteed when a hyperdose is received - an overestimation of normal values by 3-10 times or a megadose - an increase of 10-100 times or more.

For comparison, you can give the doses of vitamin A in the drug “Aevit”. The content of retinol acetate in this drug is 35 mg (more than 100,000 IU)! This is more than 10 times the maximum permissible daily dose.

Features of overdose treatment

All cases of overdose of this drug are treated the same way. First of all, this multivitamin should be discontinued. The victim is administered Mannitol, glucocorticosteroids, and Vikasol.

Mannitol lowers pressure inside the skull. This allows you to stop attacks of headaches, nausea, vomiting, and dizziness. Glucocorticosteroids accelerate the removal of excess amounts of vitamins from the body. Vikasol (vitamin K) reduces the risk of hemorrhages. All these medications must be taken until the health condition of the poisoned person is normalized.

When should you not take the drug?

There are diseases and conditions in which taking Aevita is strictly prohibited. This:

hypersensitivity to one of the vitamins;
hypervitaminosis;
age up to 14 years;
cirrhosis of the liver;
hepatitis of viral origin;
cholecystitis;
kidney failure, especially in an advanced stage;
thyrotoxicosis;
pregnancy (possibly teratogenic effects on the fetus).

So, when treating with Aevit, you must be careful. Please remember that these capsules cannot be used as a prophylactic. It should be used only on the recommendation of a doctor and in the dosages that he prescribed. Severe symptoms of poisoning may occur in persons with hypersensitivity to vitamins. If poisoning occurs, you must immediately provide first aid and call a doctor.

When does vitamin A poisoning occur?

The traditional site of vitamin A accumulation is the liver. It can contain from 100 mg to 750 mg. In the liver of animals, its content is even higher. In cases of an unusual diet, for example, a passion for cod liver, liver pate of domestic animals, the vitamin accumulates and its toxic effect manifests itself.

The indigenous people of the north do not consume seal, walrus or polar bear liver. Even a single dose will produce an excess of vitamin A and the consequences will be fatal.

Excess vitamin A is often observed in the treatment of acne, when Roaccutane and Tigazon are prescribed. And also in the treatment of eye diseases to improve vision. Purpose of "Aevit" in the treatment of infertility or problems with skin, nails, hair. There are known cases of poisoning from long-term use of fish oil. Vitamin A should not be taken with estrogen-containing drugs, as this leads to increased absorption and the risk of overdose.

Treatment of rickets and infectious diseases requires the administration of large doses. The gradual accumulation of vitamin A will give a picture of poisoning.

Possibilities of the drug

Each capsule of the drug contains a significant amount of vitamins, much higher than the daily requirement (without insufficient condition).

For this reason, the drug has a therapeutic effect, but not a preventive one.

Aevit has a healing effect

This combination of vitamins A and E is very harmonious and, having a complex effect, treats many pathological conditions of the body.

Operating principle

The drug has an effect on the cell nuclei of organs, the so-called targets, and stimulates the process of synthesizing proteins and tissue structures, activates regeneration, and increases the standard and non-standard resistance of the body. Moreover, the drug optimizes metabolism, capillary circulation, increases vascular permeability, improving their resistance to oxygen starvation.

Functionality of Vitamin A

Carrots are the first product where this substance was discovered. For this reason, vitamins of this group are called carotenoids, which, translated from English, means carrots.

Vitamin A is involved in preserving and prolonging youth

This group is involved in:

ORP;
regulation of the process of protein formation;
optimization of metabolism;
formation of bone tissue, teeth;
the formation of new cells and fat deposits;
preserving and prolonging youth.

Moreover, retinol is indispensable in restoring visual functions. It is also involved in activating the immune system in the fight against infectious diseases. Thanks to it, the barrier ability of the mucous membranes improves.

The cells of the surface layer of the skin (epithelium) and organs have a great need for it. Therefore, it is effective in the fight against psoriasis, acne, and wrinkles.

By participating in the process of collagen synthesis, it promotes rapid healing of skin damage.

Retinol brings great benefits to the fetus, providing good nutrition for proper development and growth.

Retinol maintains favorable hormonal levels, optimizes the functioning of the cardiovascular system and circulatory systems, prevents the formation of cholesterol plaques, and protects cell membranes from harmful environmental influences.

Functionality of vitamin E

This substance was found in oil from sprouted wheat grains. The name "tocopherol" comes from the Greek "tokos", which means birth, and "ferro" - to wear.

Tocopherol strengthens and activates the immune system, optimizes the functioning of the heart muscles. By thinning the blood and successfully cleansing blood vessels, it prevents the formation of blood clots and plaque deposits.

Similar to retinol, it is involved in the process of hormone synthesis.

The uniqueness of this vitamin is that it is able to form new blood vessels in the event of failure of any area due to the formation of a blood clot.

Its effect on the body is:

Vitamin E protects cells from free radicals

protecting lipids inside cells from the action of free radicals and stabilizing them;
control of enzyme function in cell membranes;
formation of the gonads (insufficient levels of this vitamin in a teenager’s body can lead to impaired sexual development);
eliminating the causes leading to atherosclerosis and other CV diseases;
providing oxygen supply to cells.

However, tocopherol itself is not produced. The body receives it with food. The place of its accumulation is adipose tissue. If there is a lack of fat, it will not be absorbed by the body, because under such conditions it is not broken down.

Purpose

Aevit shows excellent results in the treatment of diseases that require long-term administration of a complex of vitamins A and E in large quantities:

Used in the treatment of optic atrophy

psoriasis;
vascular damage of an atherosclerotic nature;
deterioration of tissue trophism;
retinitis pigmentosa;
obliterating endarteritis;
optic nerve atrophy;
lupus erythematosus.

Contraindications

As mentioned above, this drug has a therapeutic load, and not a preventive one, because it contains an increased dosage of components. This determines the existence of certain contraindications. Among them:

individual intolerance to components;
thyrotoxicosis;
circulatory failure and glomerulonephritis in chronic form;
pregnancy;
children under 14 years of age (due to too high dosage).

Side effects

The high dosage composition also causes the presence of side effects. Among them:

Long-term use may aggravate gallstone disease

allergic manifestations;
dyspeptic disorders;
pain in the abdominal area;
nausea;
loose stool.

Long-term use can provoke an exacerbation of cholelithiasis, pancreatitis in acute or chronic form.

Not often, but it is possible to develop hypervitaminosis A in a chronic form, expressed by:

lesions of the central nervous system (dizziness, sleep disturbances, apathy, excessive irritability, paresthesia, headaches and muscle pain);
changes in the skin surface (dryness, manifestations of seborrhea, hair loss);
arthralgia;
enlarged spleen or liver;
impaired coordination of movements and gait.

Special Recommendations

Due to the presence of side effects, the medication should be used with extreme caution by people with myocardial infarction, suspected thromboembolism, acute or chronic nephritis, and severe atherosclerosis of the coronary arteries.

This product should not be taken with other medications that contain vitamins A, estrogens, nitrites, or cholestyramine, which interfere with the absorption of vitamin A.

It is important to know that retinol can reduce the anti-inflammatory effect of GCS.

Indications for use

Aevit contains two vitamins - A (retinol palmitate) and E (alpha-tocopherol acetate), which are immunostimulants and antioxidants. During treatment with Aevit, the patient's capillary circulation is restored, the permeability of blood vessels and tissues improves, cells are better saturated with oxygen, and a rejuvenating effect occurs. One capsule of the vitamin complex contains more than the daily intake of active substances, so Aevit should be taken only with the permission of a doctor.

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Vitamins help overcome the following diseases:

cystic fibrosis of the pancreas;
hyperthyroidism;
lupus erythematosus;
night blindness;
optic nerve atrophy;
obstruction of the bile ducts;
alcohol or drug addiction;
cirrhosis of the liver;
vascular atherosclerosis;
peripheral neuropathy;
chronic cholestasis;
diarrhea;
psoriasis;
long-term stress.

Drinking Aevit is recommended for those who regularly go on diets and, as a result, do not receive the necessary nutrients with food. The drug is sometimes indicated for women during pregnancy and for people who have had a gasterectomy.

Consequences of overuse

The intake of vitamins, the accumulation of which we are trying to replenish, should have a reasonable limit. Vitamins, including A and E, receive special attention. Regarding them, the ancient Greek wisdom is known: the degree of their dosage is on the verge of threatening hypovitaminosis and no less dangerous hypervitaminosis.

Daily norms

Do not exceed the daily dose

The standard dose of the drug is 1-2 capsules twice or thrice a day. In this case, the time of taking the medicine does not depend on food intake.

The duration of the treatment course depends on the recommended dosage and ranges from 10 days to 4-6 weeks. The course is repeated no earlier than 3 months, and then only if indicated.

Treatment is usually carried out twice a year, unless otherwise prescribed by a doctor.

Possibility of toxemia

An overdose of aevit can occur due to an excessive amount of it in the human body, which is possible if the recommended standards are violated.

Symptoms begin to develop approximately 6 hours after taking the drug.

If you take Aevit for a long time, an overdose will have the following symptoms:

high blood pressure;
abnormal blood composition (decrease in platelet and leukocyte counts);
decreased calcium in the bloodstream and poor absorption;
impaired renal and liver function;
enterocolitis;
accumulation of fluid in the peritoneum;
weakness of blood vessels, leading to their rupture and the formation of bruises.

Elimination of the consequences of intoxication

Corn oil will remove excess retinol

If the overdose was minor, then you can do it on your own without resorting to the help of doctors. However, with the dynamic development of symptoms, the help of a specialist is necessary.

Pre-medical actions

Self-help consists of standard steps: gastric lavage and taking sorbents.

If hypervitaminosis is observed, it is recommended to drink corn oil with the drug. The course consists of 1 tbsp. twice or thrice a day before meals.

The oil, having an excellent choleretic effect, will remove excess retinol. Moreover, it is an antidote to vitamin E.

Health care

Signs indicating poisoning may appear in people with problems of the thyroid gland, blood supply, heart, kidneys and blood vessels, in the presence of cholecystitis. Such cases require the help of a physician.

Treatment tactics consist of the following:

mannitol (to eliminate intracranial pressure, dizziness, nausea);
glucocorticoid hormones (to speed up the process of elimination of substances);
vikasol (to eliminate the risk of hemorrhage).

Additionally, symptomatic therapy is carried out.

Description of aevit

The drug is very useful, since the vitamins included in its composition normalize metabolism and are active antioxidants. The action is aimed at restoring capillary blood circulation, improving tissue and vascular permeability, reducing the possibility of oxygen starvation in tissue cells, generally strengthening the body, and improving well-being.

Each Aevit capsule contains a very large dose of vitamins, which significantly exceeds the daily dose without a deficiency condition, so the drug is therapeutic, not preventive.

This combination of retinol (vitamin A) and tocopherol (vitamin E) is very harmonious and has a complex effect and treatment of certain pathological conditions of the body.

Effect of vitamin A

Vitamin A is an essential element for the normal functioning of the body.
The first product in which this vitamin was discovered was carrots. That is why the group of vitamins A is called carotenoids, which in English means “carrot” vitamins. Effect on the body:

redox processes;
regulation of protein synthesis;
normalization of metabolism;
one of the vitamins that forms bones, teeth and fat deposits;
forms new cells;
prolongs youth.

In addition, retinol is an indispensable tool for restoring all vision functions and their normal functioning. Participates in normalizing the immune system and fighting infections. When taking this vitamin, the barrier function of the mucous membranes increases, due to which viral infections occur less frequently, and sick people tolerate even complex infections much easier.

Human epithelium, that is, cells on the surface of the skin and internal organs, needs retinol. Thanks to this, many beauties use this product to restore the youth and beauty of their skin. It helps fight acne, wrinkles, psoriasis and other skin diseases. Since the epithelium makes up the surface of internal organs, the vitamin is also useful for them. It can become part of complex therapy in the treatment of lung and gastrointestinal diseases.

Thanks to its participation in collagen synthesis, retinol promotes good healing of wounds; skin saturated with it becomes qualitatively better and more actively resists infections. For a baby during intrauterine development, it is vital and helps the fetus develop and receive sufficient nutrition for growth.

Among other things, retinol is necessary for a favorable hormonal balance, prevents the development of cancer cells, protects cell membranes from the harmful effects of external factors, ensures the proper functioning of the heart and circulatory system, and prevents the appearance of cholesterol plaques.

Effect of vitamin E

Tocopherol strengthens the immune system and normalizes the activity of the heart muscle. It thins the blood and cleanses the blood vessels, preventing plaques from being deposited on them and blood clots from forming. Similar to vitamin A, it also participates in the synthesis of hormones.

The unique property of tocopherol is that this antioxidant is able to form a new blood vessel if a certain section along this path fails due to thrombosis.

Effect on the body:

stabilization and protection of unsaturated lipids in cells from free radicals;
control of the work of enzymes in cell membranes, ensuring free access of useful substances;
has a direct effect on the gonads, participating in their formation and functioning. Lack of tocopherol in adolescents can lead to sexual dysfunction;
prevents the development of atherosclerosis and other cardiovascular diseases;
enriches cells with oxygen, facilitating its unhindered access.

Aevit overdose: symptoms and help

An overdose of aevit, like other vitamins, is more dangerous for children. The child’s body does not always cope with incoming microelements due to not fully developed immunity and other functions. Foreign or unfamiliar substances entering the blood can be perceived with hostility, especially in cases where their quantity is exceeded. So, from eating an Aevit capsule sold in a pharmacy, a child may develop an allergic reaction with many unpleasant symptoms. These include the development of atopic dermatitis, urticaria, and in particularly dangerous cases, if the child has an intolerance to one or more active substances, angioedema may develop. The latter syndrome is dangerous due to suffocation, so if there is a suspicion of an overdose of Aevit, you should seek help from a doctor and give the child any antihistamine - Suprastin, Zyrtec, etc.

An allergic reaction is also possible in adults, since this vitamin supplement tends to accumulate in the body and lead to an overdose, which can be critical.
Allergy to excess vitamin content in adults is mild, but it is still necessary to stop using the drug until all symptoms disappear. The drug should be restarted after consultation with your doctor; it is also advisable to recalculate the dosage, increasing it gradually.
Excessive levels of aevita in the body lead to high blood pressure. With long-term use in children, the composition of the blood is disrupted, since aevit reduces the number of platelets and leukocytes. The drug can also reduce the amount of calcium in the blood and interfere with its absorption.

Weakness, drowsiness and decreased ability to work can also become a symptom of an overdose of Aevit, since in this case the work of the liver and kidneys is inhibited at the cellular level.

Signs of a drug overdose with long-term use include some problems with the gastrointestinal tract and other internal organs:

enterocolitis;
enlarged liver;
fluid in the abdominal cavity;
rupture of blood vessels with the formation of bruises and “red” eyes.

With long-term use of the drug for therapeutic purposes, it is necessary to regularly take a biochemical blood test to determine the presence and amount of microelements in the blood and check the liver.

Help with an overdose of aevit

For hypervitaminosis aevita, you can take 1 tablespoon of corn oil 2-3 times a day before meals. Being a good choleretic agent, it will remove excess vitamin A. In addition, any vegetable oil is an antidote to vitamin E.

An overdose is possible if a person has problems with the thyroid gland, chronic and acute kidney diseases, insufficient blood supply, heart and vascular diseases, or cholecystitis. In these cases, you should seek help from a specialized specialist.

In case of an overdose of Aevit in children, you need to give sorbents: activated carbon, polysorb and contact an ambulance. If a large amount of the drug is eaten, gastric lavage may be necessary.

When taking Aevita in the first months of pregnancy and while breastfeeding, you should seek help from your doctor.

What is the danger of an overdose of vitamin A in children?

The most serious complication of increased intake of vitamin A into a child’s body is bulging of the fontanelles and the appearance of fluid in the brain (hydrocephalus). Spontaneous bleeding occurs due to liver damage, bleeding gums appear, and nosebleeds are typical.

An overdose of vitamin A in children leads to:

to increased activity (excitement);
increase in temperature;
lack of appetite;
hair begins to fall out;
seborrhea appears.